Sorry for the delay in responding – I wanted to pool the committee to be sure I was not speaking off the top of my head 🙂

1.  Six cells is enough to ensure the reader can find the page numbers…you do not need to expand that margin if you have really long page numbers.  I will look into clarifying that in Formats.
2. I found this question a bit confusing.  If you have 21ST CENTURY SKILLS you would start the passage indicator after 21 – even though it looks really weird – and terminate it after SKILLS.  If 21ST CENTURY is also italicized, you would need to keep that for distinction.  For that, use italic word indicators on each word.
3. Because the “definition” on the special symbols page says acute accent above the following letter, one entry works for both the lowercase and uppercase letters.

Cindi